Janet Nale

Lecturer, Centre for Epidemiology and Planetary Health · Department of Veterinary and Animal Science

Author

APID: 3158
ORCID: https://orcid.org/my-orcid?orcid=0000-00
Google Scholar: https://scholar.google.co.uk/citations?user=Teek3bsAAAAJ&hl=en
Location: Inverness, Scotland, United Kingdom
Expertise: Bacteriophages, bioinformatics
Areas of interest: Zoonotic infections
Member since: August 2023

Biography

Janet is a microbiologist with significant experience working on bacteriophages (phages- viruses of bacteria) to control zoonotic bacteria such as Clostridioides difficile, Salmonella enterica and Escherichia coli. Janet has spent over a decade developing and formulating therapeutic phage cocktails for optimal stability and pH-target delivery to effectively control the bacteria in gut conditions, focusing on activity in vitro (pure cultures and biofilms), ex vivo (pig IPEC-1, chicken CHIC-8E11 and human HT-29 cell lines, and gut batch fermentation) and in vivo (Galleria mellonella and hamster) infection models. Janet’s work has also established how phages interact with and regulate host gut microbiomes and expression of immune, growth and reproductive markers during bacterial infection and recuperation when undergoing phage therapeutic intervention. All aspects of Janet’s research were jointly funded by commercial biopharmaceutical companies and research grants.