Dr. Ratnakar Tripathi

Assistant Professor · Veterinary Medicine and Surgery

University of Missouri Columbia

Author

APID

5295

ORCID

0000-0002-7398-8115

Location

Columbia, MO, United States

Expertise

Corneal Wound Healing and Gene Therapy

Areas of interest

Ophthalmology

Member since

December 2023

Biography

I am an ocular researcher with a background in human genetics, cellular and molecular biology, and vision science. My research interests are ocular diseases and their molecular basis of disease pathogenesis, and the development of therapeutic approaches to prevent blindness. I have earned Ph.D. degree from the Banaras Hindu University, India, and studied and reported putative interactors of Pax6 (a master regulator gene of the brain and eye development). The Pax6 interactors are critical in regulating neuronal plasticity, migration, and modulating memory formation, and play an important role in brain aging. In 10 years of my research career, I have worked on human genetics, neuroscience of brain aging, memory formation, and ocular research, published several research articles in National and International peer-reviewed and indexed journals, co-authored a book chapter, and received multiple awards from National and International organizations. Currently, at the University of Missouri, Columbia, USA, I am working on corneal wound healing biology, gene therapy, epigenetic, and nanomedicine approaches to treat corneal fibrosis. My current research is focused on studying corneal fibrosis and the toxicity of chemicals to the eye.

Publications

1. Kumar R, Sinha DM, Lankau BR, Sinha NR, Tripathi R, Gupta S, Mohan RR. Differential gene expression and protein-protein interaction network profiling of sulfur mustard-exposed rabbit corneas employing RNA-seq data and bioinformatics tools. Exp Eye Res. 2023 Sep 6:109644. doi: 10.1016/j.exer.2023.109644.
2. Mohan RR, Balne P, Muayad M, Tripathi R, Sinha N, Gupta S, An J, Sinha P, and Hesemann N. Six-month in vivo safety profiling of topical ocular AAV5-Decorin gene transfer. Transl Vis Sci Technol. 2021; 12;10(10):5.
3. Sinha NR, Tripathi R, Balne PK, Mohan RR, Chaurasia SS. Time-dependent in situ structural and cellular aberrations in rabbit cornea in vivo after mustard gas exposure. Exp Eye Res. 2022. 224:109247.
4. Sinha NR, Tripathi R, Balne PK, Suleiman L, Simkins K, Chaurasia SS, Mohan RR. Mustard Gas Exposure Actuates SMAD2/3 Signaling to Promote Myofibroblast Generation in the Cornea. Cells. 2023; 12(11):1533.
5. Tripathi R, Balne PK, Sinha NR, Martin LM, Kamil S, Landreneau JR, Gupta S, Rodier JT, Sinha PR, Hesemann NP, Hofmann AC, Fink MK, Chaurasia SS, Mohan RR, A novel topical ophthalmic formulation to mitigate acute mustard gas keratopathy in vivo: A pilot study. TVST. 2020, 2; 9 (12):6.
6. Tripathi R, Sinha NR, Kempuraj D, Balne PK, Landreneau JR, Juneja A, Webel A, Mohan RR. Evaluation of CRISPR/Cas9 mediated TGIF gene editing to inhibit corneal fibrosis in vitro. Exp. Eye Res. 2022; 220:109113.