Dr. Bac Viet Le
- APID
- 5459
- Google Scholar
- https://scholar.google.com/citations?user=li2JO0AAAAAJ&hl=en
- Location
- Philadelphia, Pennsylvania, United States
- Expertise
- Cancer Biology, Cell/Molecular Biology
- Areas of interest
- Leukemia, DNA damage/repair, synthetic lethality
- Member since
- January 2024
Biography
I am a Postdoctoral Fellow Research Associate with 8 years of experience in Cell Biology, Cancer Biology and Hematological Oncology, as well as 13 years in Molecular Biology and Biochemistry, specializing on investigate DNA damage and repair for drugs/therapeutic discovery. My current area of expertise is to explore and develop novel precision medicine-guided therapies to treat leukemias and other types of hematopoietic malignancies by exploiting DNA repair inhibitors inducing synthetic lethality. I am strongly focusing on cancer mechanistic research in both in vitro and in vivo, to highlight the features of Translational Biology in my studies. Based on my entire research endeavors, I have a solid background knowledge and experimental skills in Cell Biology, Cancer Biology, Molecular Biology, DNA damage/repair pathways, and the interplay of DNA methylation alteration with DNA repair capacity.
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Sign inPublications
- 4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells
- DNA polymerase θ protects leukemia cells from metabolically induced DNA damage
- Pre-Existing and Acquired Resistance to PARP Inhibitor-Induced Synthetic Lethality
- TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair andSensitivity of Leukemia Cells to PARP Inhibitors
- TGFβR-SMAD3 signaling induces resistance to PARP inhibitors in the bonemarrow microenvironment
- Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors